Why Are Some Parkinson Disease Patients Unaware of Their Dyskinesias?

Anosognosia - for - dyskinesias in PD 1 Running head : ANOSOGNOSIA - FOR - DYSKINESIAS IN PD Why are some Parkinson ’ s disease patients unaware of their dyskinesias ? Paul

Objective: To test the hypothesis that anosognosia-for-dyskinesias in Parkinson’s disease (PD) results from a failure to detect discrepancies between intended and actual movement. Background: PD patients often complain of drug-induced dyskinesias (involuntary movements) less than their carers. This remarkable unawareness is an example of anosognosia (i.e., unawareness of deficits associated wit...

All Ranks Are Local: Why Humans Are Both (Painfully) Aware and (Surprisingly) Unaware of Their Lot in Life

Are Game Platforms suitable for Parkinson Disease patients?

Parkinson's Disease (PD) is a progressive neurodegenerative movement disorder that affects more that 6 million people worldwide. Motor dysfunction gradually increases as the disease progress. It is usually mild in the early stages of the disease but it relentlessly progresses to a severe or very severe disability that is characterized by increasing degrees of bradykinesia, hypokinesia, muscle r...

Why are some human disease-associated mutations fixed in mice?

analysis of the mouse genome. Nature 420, 520–562 19 Eickbush, T.H. and Furano, A.V. (2002) Fruit flies and humans respond differently to retrotransposons. Curr. Opin. Genet. Dev. 12, 669–674 20 Malik, H.S. et al. (1999) The age and evolution of non-LTR retrotransposable elements. Mol. Biol. Evol. 16, 793–80520 21 Jurka, J. (2000) Repbase update: a database and an electronic journal of repetiti...

Factors associated with the development of motor fluctuations and dyskinesias in Parkinson disease.

BACKGROUND Motor fluctuations and dyskinesias can cause disability and reduce quality of life for patients with Parkinson disease (PD). OBJECTIVES To evaluate factors associated with the development of motor fluctuations and dyskinesias and to assess the sequence in which they occur in individual patients. DESIGN We performed a retrospective analysis of data from a randomized clinical trial...